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Antibiot Khimioter.
2002;47(2):20-3. |
Glutoxim in the complex treatment of tuberculosis.
[Article
in Russian]
Sokolova GB, Sinitsyn MV, Kozhemiakin LA,
Perelman MI.
Research Institute of
Phthisiopulmonology, I. M.
Results of Glutoxim investigation are presented. Glutoxim is the the drug of
the new class--thiopoietins. It is considered to be immunorehabilitator as it
modulates intracellular process of thiols metabolism, initiates cytokins
system, activates phagocytosis etc. Results of the glutoxim administration at
the 42 patients with tuberculosis using traditional treatment regimes are
presented. Results of the randomized study at the patients with severe
disseminated drug-sensitive and drug-resistant pulmonary tuberculosis
demonstrated high efficacy of the glutoxim and its good tolerability. Glutoxim
administration allowed to shorten the period of tuberculosis intoxication signs
disappearance, to shorten the period of sputum negativation and shortened the
period of pulmonary inflammation reverse process. Glutoxim application was
specially favorable at the patients with severe tuberculosis complicated by
viral or medicamental hepatitis.
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