|
Antibiot Khimioter.
2002;47(6):18-21. |
Effect of glutoxim in the combination with
antitubercular agents of the second choice on the growth of drug resistant
Mycobacteria tuberculosis in the cultured murine lung tissue.
[Article in Russian].
Kunichan AD, Sokolova
GB, Perel'man MI.
Research
Institute of Phthisiopulmonology,
It was demonstrated that glutoxim combination with second line drugs for
tuberculosis treatment (cycloserine + rifabutine, cycloserine + protionamide) provided
statistically significant decrease of intracellular mycobacteria growth in the
murine lung tissue culture. The decrease rate when compared to the control
group was 3-5 times. The investigated Mycobacterium tuberculosis strain was
isolated from the patient and was multi-drug resistant (MDR). Glutoxim addition
to the second line drugs combinations provided also decrease of the MDR
bacteria microcolonies growth in the lung tissue culture. Glutoxim combination
with second line antituberculosis drugs allowed to keep vitality and functional
activity of lung tissue cells.
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