Epiphamin – endocrine system
bioregulator
Epiphamin is produced from the
cattle and pig pineal gland. It is a nucleoprotein complex, which acts
selectively on pineal cells promoting hormonal metabolism, immunity correction
and blood coagulability system.
Clinical trials were conducted on
227 patients with chronic hormonal myocardiodystrophy, physiogenic asthenia,
pronounced manifestations of female climacteric period, as well as cancer
patients undergoing chemo- and radiotherapy. Control groups consisted of 156
similar patients who underwent standard treatment.
Epiphamin effectiveness was
estimated on the basis of standard methods of investigation. There was
evaluated the dynamics of patients complaints, as well as clinical blood and
urine tests, blood biochemistry and ECG. With the aid of immunological methods
there was estimated the amount and functional activity of lymphocytes in
peripheral blood. The contents of hormones (FSG and LG) in the blood serum was
registered by radioimmunological method. Correction test and that of Luescher
were used for estimation of psychophysiological indices.
In the process of epiphamin
treatment, the patients with hormonal myocardiodystrophy noted the improvement
of subjective indices of the disease, i.e. less frequency of heart attacks,
increased working capacity and normalization of psycho-emotional state.
Positive ECG dynamics was marked, as well. The study of hormone level in the
blood serum revealed the the decrease of FCG content as compared to the initial
level in the absence of significant changes in LG and prolactin concentrations.
The conducted trials evidenced
regulatory influence of epiphamin on disturbed hormonal balance permitting to
normalize myocardial metabolism.
The results of physiogenic asthenia
treatment showed high effectiveness of epiphamin in elimination of subjective
neurological symptoms. Most pronounced therapeutic effect was traced in
patients with cephalgic syndrome, signs of non-systemic dizziness, emotional
lability, as well as in those complaining pronounced weakness, increased
weariness and sleep disturbances. Stable after-effect was very vivid. Thus, in
one month, such symptoms as dizziness, ear noises, general weakness, increased
weariness, pelvic dysfunctions, sleep disturbances and cephalgies practically
disappeared.
Less pronounced but distinct
dynamics was registered with respect to the number of objective neurological
indices closely connected with central regulation of vegetative functions.
Epiphamin produced smoothing effect on pseudobulbary symptoms. In the process
of epiphamin administration, white stable dermographism became weaker. Focal
symptoms became more even, as well, in the period of treatment accompanied by
long-term after-effects.
Thus, epiphamin application seems to
be prospective in treatment of physiogenic asthenias, including those,
accompanied by psycho-vegetative disturbances.
Epiphamin was given to a number of
cancer patients, largely with hormone-dependant tumors (breast and cervical
cancers, as well as other sites).
All patients revealed steady
leukopenia and lymphocytopenia (during 6 months – 1,5 year) after chemo- and/or
radiotherapy. Epiphamin was applied for stimulation of immuno- and hemopoiesis
in order to prepare patients for subsequent complex of treatment.
The majority of patients were
examined prior to, immediately after and in 20-30 days after epithalamin
application for the amount of leukocytes in the peripheral blood and T- and B-
immunity systems indices.
The patients with initially steady
decreased blood level of leukocytes revealed significant increase of the total
amount of lymphocytes and T-lymphocytes following epiphamin treatment, as well
as the improvement of T-cell functional activity. The patients marked muscular
tension increase and appetite improvement.
Epithalamin intake by cancer
patients subject to radio- and chemotherapy permits to improve general state of
the organism, hematological and immunological blood indices preventing
development of infectious and other complications.
Chemical structure
and nutritional value of Epiphamin:
|
Nutritional
substances, % |
Vitamins,
mg/10 mg |
||
|
Protein
|
57,3
|
Thiamin(B1)
|
0,08
|
|
Fats
|
0,99
|
Riboflavin(B2)
|
0,038
|
|
Carbohydrates
|
<0,01
|
Niacin(PP)
|
0
|
|
Ashes
|
1,40
|
Retinol(A)
|
0,024
|
|
|
à-Tocopherol(E)
|
0,054
|
|
|
Mineral
substances, mg/10mg |
Aminoacids,
nmol/mg |
||
|
Aluminium
|
0,4134
|
Asparagine
|
307
|
|
Cobalt
|
0,0011
|
Threonine
|
133
|
|
Copper
|
0,1950
|
Serine
|
159
|
|
Iron
|
2,40
|
Glutamine
|
446
|
|
Magnesium
|
1,565
|
Proline
|
109
|
|
Calcium
|
25,69
|
Glycine
|
208
|
|
Potassium
|
54,95
|
Alanine
|
238
|
|
Sodium
|
981,70
|
Valine
|
157
|
|
Manganese
|
0,019
|
Methionine
|
0
|
|
Molybdenum
|
0,012
|
Isoleucine
|
110
|
|
Phosphorus
|
41,53
|
Leucine
|
262
|
|
Sulfur
|
201,5
|
Tyrosine
|
72
|
|
Zinc
|
13,06
|
Phenylalanine
|
93
|
|
Lead
|
0
|
Histidine
|
95
|
|
Cadmium
|
<0,001
|
Lysine
|
176
|
|
|
Arginine
|
209
|
|
Epiphamin is recommended for
normalization of hormone metabolism, regulation of immunity and blood
coagulability system in different forms of their disturbances, including states
caused by radio- and chemotherapy. It is also recommended to the elderly for
maintaining endocrine system functions.
No side effects have been
registered.
It should be stored in a dry cool
light protected place.
Dr. Giorgio Castello
Via A. Cecchi, 19/9
16129 – Genova (Italy)
Phone:
Mobil
phone :
e-mail:
castello@tiopoietine.info