A study of hemostimulating properties of Glutoxim
in non-small cell lung carcinoma (NSCLC) patients undergoing cytostatic
chemotherapy.
V.A.Gorbunova, N.V.Mindra, L.A.Kozhemyakin, I.V.Ose.
Purpose: To study the
efficacy of Glutoxim in preventing hematological toxicity of anti-tumor
chemotherapy; to evaluate therapeutic efficacy of Vepezide + Cisplatin
treatment concomitantly with Glutoxim therapy.
Methods: Within the
framework of the study with a case history control group, stage III-IV NSCLC
patients received chemotherapy according to the following regimen: Vepezide
100 mg/m2 intravenously on days 1-3, Cisplatin 100 mg/m2
intravenously on day 3, Glutoxim 60 mg intramuscularly for 4 days
before chemotherapy course, 90 mg intravenously on days 1-3, 60 mg
intramuscularly on days 4-6 and subsequently 30 mg intramuscularly every
other day until the beginning of the next course of chemotherapy. Clinical blood
analysis was performed every week.
Results: Thirty
49-74year old patients received 124 chemotherapy courses. Results of
103 courses were evaluated for toxicity according to WHO criteria.
Leucopenia: I-II degree 48 (46.6%) courses, III-IV degree 5 (4.85%)
courses, not registered 50 (48.55%) courses. Neutropenia: I-II
degree 54 (52.43%) courses, III-IV degree 12 (11.65%) courses,
not registered 37 (35.92%) courses. Thrombocytopenia: I-II degree
17 (16.5%) courses, III degree 6 (5.83%) courses, in 80 (77.67%) courses
no decrease of platelet count was observed. Anemia: I-II degree 58
(56.31%) courses, III degree 7 (6.80%) courses, not registered 38
(36.89%) courses. No cases of IV degree anemia or thrombocytopenia or episodes
of febrile neutropenia were registered. In 1 patient III degree anemia
necessitated administration of erythropoietin. Treatment efficacy was evaluated
in 29 patients. Partial effect, stabilization and disease progress were
observed in 10 (34.48%), 12 (41.38%) and 7 (24.14%) patients, respectively;
tumor growth control was observed in 75.86% of patients.
Conclusions: Standard
chemotherapy according to ER regimen does not cause profound hematological
toxicity when given concomitantly with Glutoxim therapy.
For more references:
Dr. Giorgio Castello
Via A. Cecchi, 19/9
16129 Genova (Italy)
Tel:
Mobil
phone:
e-mail:
castello@tiopoietine.info