Trial for Inhalation Introduction of Glutoxim-Containing Formulation in
Children Patients with COPD.
T.Y.
Gembitskaya, M.A. Zaitseva, L.A. Kozhemyakin, A.V. Molodtsova
BAM R&D Laboratories, Ltd,
The aim was to learn
efficacy of inhalation administration of the Glutoxim-containing formulation
and therapeutic agents for basic inhalation treatment in chronically
obstructive pulmonary disease (COPD) patients. Sixteen patients having
prevailing pulmonary form of the COPD with signs of exacerbation of
infectious-inflammation process at the time of the study were enrolled. The
patients were distributed into two arms - experimental (I) and control (II).
The group I patients were treated with antibacterial therapy and daily
inhalations of Glutoxim and cofactors through nebulizer during 10 days. The
group II patients were administered with antibacterial, mucolytic agents and
daily inhalations of anticholinergic and b-adrenomimetic agents through
nebulizer. By the end of the study clinical indices in the groups I and II
were found to have significant changes indicated with diminution of dyspnea,
coughing, amount of sputum, decreased sputum viscosity and lowered number of
rales. The external respiration parameters indicated improved bronchial patency
both in the groups I and II (significant 10-15% increase of FEV1 and PEFR
comparing to the baseline data). There were not found any significant
differences between groups I and II.
The patients noted good
tolerance for the new formulation and absence of undesirable side effects. We
conclude that the Glutoxim-containing formulation introduced through nebulizer
application in the COPD patients has effective broncholytic and
anti-inflammatory activity comparable with the conventional inhalation therapy.
The drug effects are determined with mutually potentiating action of the active
formulation components by regulation of the inflammatory process development in
a bronchial wall and restoration of lung antibacterial protection.
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